Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation
Episode von Medizin - Open Access LMU - Teil 20/22 von Ludwig-Maximilians-Universität München · 1. Juli 2012
Fibrinogen is a target of autoimmune reactions in rheumatoid arthritis (RA). Fibrin(ogen) derivatives are involved in inflammatory processes and the generation of a stable fibrin network is necessary for sufficient inflammation control. As the density and stability of fibrin networks depend on complex interactions between factor XIIIA (F13A) and fibrinogen genotypes, the authors studied whether these genotypes were related to C-reactive protein (CRP) levels during acute-phase reactions.
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