Medizin - Open Access LMU - Teil 20/22

von Ludwig-Maximilians-Universität München · Bildung

Die Universitätsbibliothek (UB) verfügt über ein umfangreiches Archiv an elektronischen Medien, das von Volltextsammlungen über Zeitungsarchive, Wörterbücher und Enzyklopädien bis hin zu ausführlichen Bibliographien und mehr als 1000 Datenbanken reicht. Auf iTunes U stellt die UB unter anderem eine Auswahl an elektronischen Publikationen der Wissenschaftlerinnen und Wissenschaftler an der LMU bereit. (Dies ist der 20. von 22 Teilen der Sammlung 'Medizin - Open Access LMU'.)

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Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress
1. Oktober 2012
When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and…
Movement kinematic after deep brain stimulation associated microlesions
1. Oktober 2012
Deep brain stimulation is widely used for the treatment of movement disorders such as Parkinson's disease and dystonia. After the implantation of electrodes an immediate…
Multiple pathways of plasmid DNA transfer in Helicobacter pylori
20. September 2012
Many Helicobacter pylori (Hp) strains carry cryptic plasmids of different size and gene content, the function of which is not well understood. A subgroup of these plasmids (e.g.…
Medical futility at the end of life: the perspectives of intensive care and palliative care clinicians.
1. September 2012
Medical futility at the end of life is a growing challenge to medicine. The goals of the authors were to elucidate how clinicians define futility, when they perceive…
Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals
1. September 2012
Changes in air temperature are associated with an increase in cardiovascular events, but the role of procoagulant and proinflammatory blood markers is still poorly understood.…
Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection.
1. September 2012
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of…
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects
1. September 2012
Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been…
A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseases
6. August 2012
Background In the last years GWA studies have successfully identified common SNPs associated with complex diseases. However, most of the variants found this way account for only…
Pantothenate kinase-associated neurodegeneration
1. August 2012
Pantothenate kinase-associated neurodegeneration (PKAN) is a hereditary progressive disorder and the most frequent form of neurodegeneration with brain iron accumulation (NBIA).…
Quantitative Expression of C-Type Lectin Receptors in Humans and Mice
1. August 2012
C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species-and…
Quality appraisal in systematic reviews of public health interventions: an empirical study on the impact of choice of tool on meta-analysis
31. Juli 2012
Introduction Systematic reviews are a cornerstone of evidence-based public health. The method of appraising the quality of different intervention and observational study designs…
Decidual Macrophages Are Significantly Increased in Spontaneous Miscarriages and Over-Express FasL
23. Juli 2012
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring…
Thure von Uexkülls semiotisches Modell des Menschen als Grundlage für eine moderne Theorie der Homöopathie
12. Juli 2012
Während die konventionelle moderne Medizin ihr Selbstverständnis und ihre Praxis weitgehend am Vorbild der konventionellen Naturwissenschaft orientiert, erhebt die Homöopathie…
Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms
1. Juli 2012
Therapy related myeloid neoplasms (t-MNs) are complex diseases originating from an interplay between exogenous toxicities and a susceptible organism. It has been hypothesised…
A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
1. Juli 2012
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG…
An international registry on autoinflammatory diseases: the Eurofever experience
1. Juli 2012
To report on the demographic data from the first 18 months of enrollment to an international registry on autoinflammatory diseases in the context of the Eurofever project.
Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation
1. Juli 2012
Fibrinogen is a target of autoimmune reactions in rheumatoid arthritis (RA). Fibrin(ogen) derivatives are involved in inflammatory processes and the generation of a stable fibrin…
Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex
1. Juli 2012
One of the most important hormones in the human stomach is the peptide gastrin. It is mainly required for the regulation of gastric pH but is also involved in growth and…
Patients' preferences in treatment for neovascular age-related macular degeneration in clinical routine 1/2
1. Juli 2012
To assess the effect of ranibizumab treatment for neovascular age-related macular degeneration (nvAMD) on patients' preferences and vision-related quality of life (VRQoL) in a…
Patients' preferences in treatment for neovascular age-related macular degeneration in clinical routine 2/2
1. Juli 2012
To assess the effect of ranibizumab treatment for neovascular age-related macular degeneration (nvAMD) on patients' preferences and vision-related quality of life (VRQoL) in a…
How family caregivers' medical and moral assumptions influence decision making for patients in the vegetative state: a qualitative interview study
1. Juni 2012
Decisions on limiting life-sustaining treatment for patients in the vegetative state (VS) are emotionally and morally challenging. In Germany, doctors have to discuss, together…
Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals 1/2
1. Juni 2012
Elevated ozone levels have been associated with cardiovascular morbidity and mortality. We investigated the effects of ozone on heart rate (HR) and repolarisation parameters in…
Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals 2/2
1. Juni 2012
Elevated ozone levels have been associated with cardiovascular morbidity and mortality. We investigated the effects of ozone on heart rate (HR) and repolarisation parameters in…
Silicon-[18F]Fluorine Radiochemistry: Basics, Applications and Challenges
1. Juni 2012
Silicon-[18F]Fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-F-18 and boron-F-18 based labeling strategies,…
The association of workflow interruptions and hospital doctors' workload: a prospective observational study
1. Mai 2012
Subjective workload in healthcare employees is suspected to be important for the performance and safety of healthcare delivery. This study investigates associations between…
Quantitative Live-Cell Imaging of Human Immunodeficiency Virus (HIV-1) Assembly
1. Mai 2012
Advances in fluorescence methodologies make it possible to investigate biological systems in unprecedented detail. Over the last few years, quantitative live-cell imaging has…
Advanced Fluorescence Microscopy Techniques-FRAP, FLIP, FLAP, FRET and FLIM
1. April 2012
Fluorescence microscopy provides an efficient and unique approach to study fixed and living cells because of its versatility, specificity, and high sensitivity. Fluorescence…
Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing
1. April 2012
Next generation sequencing has become the core technology for gene discovery in rare inherited disorders. However, the interpretation of the numerous sequence variants identified…
Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health
1. April 2012
Interleukin 1β (IL-1β) and tumor necrosis factor α(TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis…
Case-based e-learning to improve the attitude of medical students towards occupational health, a randomised controlled trial
1. April 2012
Undergraduate medical teaching in occupational health (OH) is a challenge in universities around the world. Case-based e-learning with an attractive clinical context could…
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
1. März 2012
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other…
Direct costs and cost-effectiveness of dual-source computed tomography and invasive coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease
1. März 2012
The study aims to determine the direct costs and comparative cost-effectiveness of latest-generation dual-source computed tomography (DSCT) and invasive coronary angiography for…
α-Hydroxyketone Synthesis and Sensing by Legionella and Vibrio
1. März 2012
Bacteria synthesize and sense low molecular weight signaling molecules, termed autoinducers, to measure their population density and community complexity. One class of…
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
1. März 2012
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry…
Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans
1. März 2012
Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous…
Expression of Tas1 taste receptors in mammalian spermatozoa
29. Februar 2012
Background: During their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the…
Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis
15. Februar 2012
Acanthocytes, abnormal thorny red blood cells (RBC), are one of the biological hallmarks of neuroacanthocytosis syndromes (NA), a group of rare hereditary neurodegenerative…
Transcriptional activation of the adenoviral genome is mediated by capsid protein VI.
1. Februar 2012
Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units…
Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health
1. Februar 2012
The impact of inflammatory bowel disease (IBD) on disability remains poorly understood. The World Health Organization's integrative model of human functioning and disability in…
Cortical folding influences migraine aura symptoms in CADASIL
1. Februar 2012
Migraine with aura is a hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). In contrast with the majority of CADASIL…

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Die neueste Episode „Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress“ erschien am 1. Oktober 2012.

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