Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects
Episode von Medizin - Open Access LMU - Teil 20/22 von Ludwig-Maximilians-Universität München · 1. September 2012
Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly captured on commonly used microarray genotyping platforms, their evaluation in the context of genome-wide association studies has been hindered until recently.
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