FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children
Episode von Medizin - Open Access LMU - Teil 19/22 von Ludwig-Maximilians-Universität München · 1. Januar 2012
Elevated cholesterol levels in children can be a risk factor for cardiovascular diseases in later life. In adults, it has been shown that blood lipid levels are strongly influenced by polymorphisms in the fatty acid desaturase (FADS) gene cluster in addition to nutritional and other exogenous and endogenous determinants. Our aim was to investigate whether lipid levels are determined by the FADS genotype already in children and whether this association interacts with dietary intake of n-3 fatty acids. The analysis was based on data of 2006 children from two German prospective birth cohort studies. Total cholesterol, HDL, LDL and triglycerides were measured at 10 years of age. Six single nucleotide polymorphisms (SNPs) of the FADS gene cluster were genotyped. Dietary n-3 fatty acid intake was assessed by food frequency questionnaire. Linear regression modeling was used to assess the association between lipid levels, n-3 fatty acid intake and FADS genotype. Individuals carrying the homozygous minor allele had lower levels of total cholesterol [means ratio (MR) ranging from 0.96 (p = 0.0093) to 0.98 (p = 0.2949), depending on SNPs] and LDL [MR between 0.94 (p = 0.0179) and 0.97 (p = 0.2963)] compared to homozygous major allele carriers. Carriers of the heterozygous allele showed lower HDL levels [β between -0.04 (p = 0.0074) to -0.01 (p = 0.3318)] and higher triglyceride levels [MR ranging from 1.06 (p = 0.0065) to 1.07 (p = 0.0028)] compared to homozygous major allele carriers. A higher n-3 PUFA intake was associated with higher concentrations of total cholesterol, LDL, HDL and lower triglyceride levels, but these associations did not interact with the FADS1 FADS2 genotype. Total cholesterol, HDL, LDL and triglyceride concentrations may be influenced by the FADS1 FADS2 genotype already in 10 year old children. Genetically determined blood lipid levels during childhood might differentially predispose individuals to the development of cardiovascular diseases later in life.
Weitere Episoden von „Medizin - Open Access LMU - Teil 19/22“
- Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine 1. Januar 2012
- Appraisal of WHO guidelines in maternal health using the AGREE II assessment tool. 1. Januar 2012
- Associations between blood glucose and carotid intima-media thickness disappear after adjustment for shared risk factors: the KORA F4 study. 1. Januar 2012
- Aszites, Pfortaderthrombose und hepatische Enzephalopathie bei Leberzirrhose: Aktuelle Therapieempfehlungen 1. Januar 2012
- Bioavailability, Antipsoriatic Efficacy and Tolerability of a New Light Cream with Mometasone Furoate 0.1% 1. Januar 2012
- Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. 1. Januar 2012
- Body fat free mass is associated with the serum metabolite profile in a population-based study. 1. Januar 2012
- Botulinum Toxin A for the Treatment of Keloids 1. Januar 2012
- Color in context: psychological context moderates the influence of red on approach- and avoidance-motivated behavior. 1. Januar 2012
- Comparison of Intravitreal Bevacizumab Upload Followed by a Dexamethasone Implant versus Dexamethasone Implant Monotherapy for Retinal Vein Occlusion with Macular Edema 1. Januar 2012
- Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus. 1. Januar 2012
- DRGs in Transfusion Medicine and Hemotherapy in Germany 1. Januar 2012
- Efficacy and Patient-Reported Outcomes of a New Mometasone Cream Treating Atopic Eczema 1. Januar 2012
- Evaluating Depressive Symptoms in Schizophrenia: A Psychometric Comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale 1. Januar 2012
- Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue 1. Januar 2012
Über den Podcast
Die Universitätsbibliothek (UB) verfügt über ein umfangreiches Archiv an elektronischen Medien, das von Volltextsammlungen über Zeitungsarchive, Wörterbücher und Enzyklopädien bis hin zu ausführlichen Bibliographien und mehr als 1000 Datenbanken reicht. Auf iTunes U stellt die UB unter anderem…
Ähnliche Episoden
- Die beste Runde seines Lebens — und er merkte nichts davon – CoreCheck Podcast
- Was, wenn's schiefgeht? - Wie dein Kopfkino Dich von Erfolg & glücklichen Beziehungen fernhält. – Der MagickMale Podcast – mit Orlando Owen
- Atypische Weidemyopathie: Wenn Ahornsamen zur Gefahr werden – Kernkompetenz Pferd - Pferdegesundheit mit Tierärztin Dr. Veronika Klein
- #70 Ehrlichkeit, Mut, Verbundenheit - meine Werte als Wegweiser – Funkelndes Ich
- #106 Thomas Lorenz bei der #lunchbox – Lunchbox - auf eine Runde mit einem Hund und Nina Mülhens
- Geld in der Beziehung: Wie fair ist 50:50? – Money Beats
Alle Episoden von Medizin - Open Access LMU - Teil 19/22 · Mehr Bildung-Podcasts