Inhibition of breathing after surfactant depletion is achieved at a higher arterial PCO2 during ventilation with liquid than with gas

Episode von Medizin - Open Access LMU - Teil 14/22 von Ludwig-Maximilians-Universität München · 1. Januar 2005

Background: Inhibition of phrenic nerve activity (PNA) can be achieved when alveolar ventilation is adequate and when stretching of lung tissue stimulates mechanoreceptors to inhibit inspiratory activity. During mechanical ventilation under different lung conditions, inhibition of PNA can provide a physiological setting at which ventilatory parameters can be compared and related to arterial blood gases and pH. Objective: To study lung mechanics and gas exchange at inhibition of PNA during controlled gas ventilation (GV) and during partial liquid ventilation (PLV) before and after lung lavage. Methods: Nine anaesthetised, mechanically ventilated young cats ( age 3.8 +/- 0.5 months, weight 2.3 +/- 0.1 kg) ( mean +/- SD) were studied with stepwise increases in peak inspiratory pressure ( PIP) until total inhibition of PNA was attained before lavage ( with GV) and after lavage ( GV and PLV). Tidal volume (V-t), PIP, oesophageal pressure and arterial blood gases were measured at inhibition of PNA. One way repeated measures analysis of variance and Student Newman Keuls-tests were used for statistical analysis. Results: During GV, inhibition of PNA occurred at lower PIP, transpulmonary pressure (Ptp) and Vt before than after lung lavage. After lavage, inhibition of inspiratory activity was achieved at the same PIP, Ptp and Vt during GV and PLV, but occurred at a higher PaCO2 during PLV. After lavage compliance at inhibition was almost the same during GV and PLV and resistance was lower during GV than during PLV. Conclusion: Inhibition of inspiratory activity occurs at a higher PaCO2 during PLV than during GV in cats with surfactant-depleted lungs. This could indicate that PLV induces better recruitment of mechanoreceptors than GV.

Weitere Episoden von „Medizin - Open Access LMU - Teil 14/22“

• A role for MCP-1/CCR2 in interstitial lung disease in children 1. Januar 2005
• A simple approach for protein name identification: prospects and limits 1. Januar 2005
• An extrahippocampal projection from the dentate gyrus to the olfactory tubercle 1. Januar 2005
• Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease 1. Januar 2005
• Chemokine receptor CCR1: A new target for progressive kidney disease 1. Januar 2005
• Comparing the clinical effectiveness of different new-born hearing screening strategies. A decision analysis 1. Januar 2005
• Concerted upregulation of CLP36 and smooth muscle actin protein expression in human endometrium during decidualization 1. Januar 2005
• Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock 1. Januar 2005
• Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease 1. Januar 2005
• Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution 1. Januar 2005
• Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease 1. Januar 2005
• Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis 1. Januar 2005
• Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease 1. Januar 2005
• Hahnemann's legacy in a new light - A systematic approach to the Organon of Medicine 1. Januar 2005
• 3D Analysis of chromosome architecture: advantages and limitations with SEM 1. Januar 2005

Alle Episoden von Medizin - Open Access LMU - Teil 14/22 · Mehr Bildung-Podcasts