A role for MCP-1/CCR2 in interstitial lung disease in children

Episode von Medizin - Open Access LMU - Teil 14/22 von Ludwig-Maximilians-Universität München · 1. Januar 2005

Background: Interstitial lung diseases (ILD) are chronic inflammatory disorders leading to pulmonary fibrosis. Monocyte chemotactic protein 1 (MCP-1) promotes collagen synthesis and deletion of the MCP-1 receptor CCR2 protects from pulmonary fibrosis in ILD mouse models. We hypothesized that pulmonary MCP-1 and CCR2(+) T cells accumulate in pediatric ILD and are related to disease severity. Methods: Bronchoalveolar lavage fluid was obtained from 25 children with ILD and 10 healthy children. Levels of pulmonary MCP-1 and Th1/Th2-associated cytokines were quantified at the protein and the mRNA levels. Pulmonary CCR2(+), CCR4(+), CCR3(+), CCR5(+) and CXCR3(+) T cells were quantified by flow-cytometry. Results: CCR2(+) T cells and MCP-1 levels were significantly elevated in children with ILD and correlated with forced vital capacity, total lung capacity and ILD disease severity scores. Children with lung fibrosis had significantly higher MCP-1 levels and CCR2(+) T cells in bronchoalveolar lavage fluid compared to non-fibrotic children. Conclusion: The results indicate that pulmonary CCR2(+) T cells and MCP-1 contribute to the pathogenesis of pediatric ILD and might provide a novel target for therapeutic strategies.

Weitere Episoden von „Medizin - Open Access LMU - Teil 14/22“

• A simple approach for protein name identification: prospects and limits 1. Januar 2005
• An extrahippocampal projection from the dentate gyrus to the olfactory tubercle 1. Januar 2005
• Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease 1. Januar 2005
• Chemokine receptor CCR1: A new target for progressive kidney disease 1. Januar 2005
• Comparing the clinical effectiveness of different new-born hearing screening strategies. A decision analysis 1. Januar 2005
• Concerted upregulation of CLP36 and smooth muscle actin protein expression in human endometrium during decidualization 1. Januar 2005
• Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock 1. Januar 2005
• Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease 1. Januar 2005
• Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution 1. Januar 2005
• Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease 1. Januar 2005
• Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis 1. Januar 2005
• Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease 1. Januar 2005
• Hahnemann's legacy in a new light - A systematic approach to the Organon of Medicine 1. Januar 2005
• Increased prevalence of colorectal adenomas in women with breast cancer 1. Januar 2005
• 3D Analysis of chromosome architecture: advantages and limitations with SEM 1. Januar 2005

Alle Episoden von Medizin - Open Access LMU - Teil 14/22 · Mehr Bildung-Podcasts