Studies of the dose-effect relation

Episode von Medizin - Open Access LMU - Teil 07/22 von Ludwig-Maximilians-Universität München · 1. Januar 1989

Dose-effect relations and, specifically, cell survival curves are surveyed with emphasis on the interplay of the random factors — biological variability, stochastic reaction of the cell, and the statistics of energy deposition —that co-determine their shape. The global parameters mean inactivation dose, , and coefficient of variance, V, represent this interplay better than conventional parameters. Mechanisms such as lesion interaction, misrepair, repair overload, or repair depletion have been invoked to explain sigmoid dose dependencies, but these notions are partly synonymous and are largely undistinguishable on the basis of observed dose dependencies. All dose dependencies reflect, to varying degree, the microdosimetric fluctuations of energy deposition, and these have certain implications, e.g. the linearity of the dose dependence at small doses, that apply regardless of unresolved molecular mechanisms of cellular radiation action.

Weitere Episoden von „Medizin - Open Access LMU - Teil 07/22“

• Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs 1. Januar 1989
• Adenosine, ‘pertussis-sensitive’ G-proteins, and K+ conductance in central mammalian neurones under energy deprivation 1. Januar 1989
• Atrial natriuretic factor (ANF) and renin-aldosterone in volume regulation of patients with cirrhosis 1. Januar 1989
• Cholinergic modulation of epileptiform activity in the developing rat neocortex 1. Januar 1989
• Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres 1. Januar 1989
• Determination of islet cell antibodies using an ELISA system with a preparation of rat insulinoma (RIN A2) cells 1. Januar 1989
• Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro 1. Januar 1989
• EPSPs in rat neocortical neurons in vitro. I. Electrophysiological evidence for two distinct EPSPs 1. Januar 1989
• EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs 1. Januar 1989
• Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways 1. Januar 1989
• Role of cytochrome c heme lyase in the import of cytochrome c into mitochondria 15. Dezember 1988
• Import pathways of precursor proteins into mitochondria 1. Dezember 1988
• The processing peptidase of yeast mitochondria 1. November 1988
• Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa 5. Oktober 1988
• A mutant of Neurospora crassa deficient in cytochrome c heme lyase activity cannot import cytochrome c into mitochondria 5. Juli 1988

Alle Episoden von Medizin - Open Access LMU - Teil 07/22 · Mehr Bildung-Podcasts