Atrial natriuretic factor (ANF) and renin-aldosterone in volume regulation of patients with cirrhosis

Episode von Medizin - Open Access LMU - Teil 07/22 von Ludwig-Maximilians-Universität München · 1. Januar 1989

The role of the atrial natriuretic factor and of the main counteracting sodium-retaining principle, the renin-aldosterone system, in acute volume regulation of cirrhosis of the liver has been investigated. Central volume stimulation was achieved in 21 patients with cirrhosis, 11 without and 10 with ascites, and 25 healthy controls by 1-hr head-out water immersion. Immersion prompted a highly significant (p<0.001) increase of atrial natriuretic factor plasma concentrations in cirrhotic patients without ascites from 8.5 ± 1.3 fmoles per ml to 16.5 ± 2.6 fmoles per ml, comparable to the stimulation in control subjects (6.0 ± 0.6 fmoles per ml to 13.6 ± 2.6 fmoles per ml). In cirrhotic patients with ascites, atrial natriuretic factor increase (from 7.7 ± 1.3 fmoles per ml to 11.4 ± 2.3 fmoles per ml) was blunted (p<0.05). Plasma renin activity and plasma aldosterone concentration were elevated in cirrhotic patients, especially in the presence of ascites. Following immersion, plasma renin activity and plasma aldosterone concentration were reduced similarly in all groups. Water immersion induced a more pronounced natriuresis and diuresis in control subjects than in cirrhotic patients. Neither atrial natriuretic factor nor plasma renin activity nor plasma aldosterone concentration alone correlated to sodium excretion. However, atrial natriuretic factor to plasma aldosterone concentration ratios were closely correlated to basal and stimulated natriuresis in cirrhotic patients, particularly in those with ascites. These data suggest that atrial natriuretic factor and the renin-aldosterone system influence volume regulation in patients with cirrhosis.

Weitere Episoden von „Medizin - Open Access LMU - Teil 07/22“

• EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs 1. Januar 1989
• Adenosine, ‘pertussis-sensitive’ G-proteins, and K+ conductance in central mammalian neurones under energy deprivation 1. Januar 1989
• Transient and selective blockade of adenosine A1-receptors by 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) causes sustained epileptiform activity in hippocampal CA3 neurons of guinea pigs 1. Januar 1989
• Cholinergic modulation of epileptiform activity in the developing rat neocortex 1. Januar 1989
• Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres 1. Januar 1989
• Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways 1. Januar 1989
• Determination of islet cell antibodies using an ELISA system with a preparation of rat insulinoma (RIN A2) cells 1. Januar 1989
• Studies of the dose-effect relation 1. Januar 1989
• Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro 1. Januar 1989
• EPSPs in rat neocortical neurons in vitro. I. Electrophysiological evidence for two distinct EPSPs 1. Januar 1989
• Role of cytochrome c heme lyase in the import of cytochrome c into mitochondria 15. Dezember 1988
• Import pathways of precursor proteins into mitochondria 1. Dezember 1988
• The processing peptidase of yeast mitochondria 1. November 1988
• Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa 5. Oktober 1988
• A mutant of Neurospora crassa deficient in cytochrome c heme lyase activity cannot import cytochrome c into mitochondria 5. Juli 1988

Alle Episoden von Medizin - Open Access LMU - Teil 07/22 · Mehr Bildung-Podcasts