Relation of Gallbladder Motility to Viscosity and Composition of Gallbladder Bile in Patients with Cholesterol Gallstones

Episode von Medizin - Open Access LMU - Teil 16/22 von Ludwig-Maximilians-Universität München · 1. Januar 2009

Background/Aims: Increased viscosity and supersaturation of cholesterol in gallbladder bile, as well as an impaired motility of the gallbladder, are considered to be important factors in the pathogenesis of cholesterol gallstones. However, the relation of these parameters has not yet been determined. Material and Methods: Bile viscosity (mPa.s) was measured by rotation viscosimetry and the composition of gallbladder bile was determined using standard methodology. Gallbladder motility was calculated as ejection fraction in percent of total volume 45 min after a test meal using ultrasonography in patients with gallstones prior to elective cholecystectomy. Results: The study included 35 patients with cholesterol gallstones. Viscosity of gallbladder bile ranged between 0.9 and 12.5 mPa.s (median 2.2 mPa.s) and an ejection fraction of the gallbladder of 55.4 +/- 18.3% (mean +/- SD) was determined. No significant correlation (r = 0.19, p < 0.2) between the 2 parameters could be calculated. Analysis of the composition of gallbladder bile revealed a positive correlation of all components to biliary viscosity but not to the motility of the gallbladder, with the exceptions of a negative correlation (r = 0.39, p < 0.02) between mucin concentration and the ejection fraction at 45 min after the test meal. Conclusions: The motility of the gallbladder appears to be unrelated to the viscosity of gallbladder bile or gallbladder bile composition. The negative correlation between the ejection fraction of the gallbladder and mucin concentration of gallbladder bile suggests that chronic inflammation of the gallbladder wall is associated with both an impaired motility of the gallbladder and increased mucin release into gallbladder bile. Copyright (C) 2009 S. Karger AG, Basel

Weitere Episoden von „Medizin - Open Access LMU - Teil 16/22“

• An Evolutionary Interpretation of Teleostean Forebrain Anatomy 1. Januar 2009
• Auditory Processing in Children with Specific Language Impairments: Are there Deficits in Frequency Discrimination, Temporal Auditory Processing or General Auditory Processing? 1. Januar 2009
• Beurteilung des Therapieerfolgs – konventionelle versus neue Methoden 1. Januar 2009
• Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study 1. Januar 2009
• Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling 1. Januar 2009
• Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome 1. Januar 2009
• Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival 1. Januar 2009
• Current Oncological Treatment of Patients with Pancreatic Cancer in Germany: Results from a National Survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society 1. Januar 2009
• Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves 1. Januar 2009
• Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor 1. Januar 2009
• Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) 1. Januar 2009
• Diagnostik und Therapie von Lebermetastasen bei kolorektalem Primärtumor 1. Januar 2009
• Die Evidenz der Klima- und Thalassotherapie 1. Januar 2009
• Die Homöopathie im Spannungsfeld zwischen aristotelischer und moderner Wissenschaft 1. Januar 2009
• A Technical Note on Quantum Dots for Multi-Color Fluorescence in situ Hybridization 1. Januar 2009

Alle Episoden von Medizin - Open Access LMU - Teil 16/22 · Mehr Bildung-Podcasts