Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome

Episode von Medizin - Open Access LMU - Teil 16/22 von Ludwig-Maximilians-Universität München · 1. Januar 2009

Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory factor 1 (USF1) gene variants with blood lipid levels and metabolic syndrome. USF1 is a transcription factor for APOA5. Methods: We investigated a possible interaction between these two genes on the risk for the metabolic syndrome, using data from the German population-based KORA survey 4 (1,622 men and women aged 55-74 years). Seven APOA5 single nucleotide polymorphisms (SNPs) were analyzed in combination with six USF1 SNPs, applying logistic regression in an additive model adjusting for age and sex and the definition for metabolic syndrome from the National Cholesterol Education Program's Adult Treatment Panel III (NCEP (AIII)) including medication. Results: The overall prevalence for metabolic syndrome was 41%. Two SNP combinations showed a nominal gene-gene interaction (p values 0.024 and 0.047). The effect of one SNP was modified by the other SNP, with a lower risk for the metabolic syndrome with odds ratios (ORs) between 0.33 (95% CI = 0.13-0.83) and 0.40 (95% CI = 0.15-1.12) when the other SNP was homozygous for the minor allele. Nevertheless, none of the associations remained significant after correction for multiple testing. Conclusion: Thus, there is an indication of an interaction between APOA5 and USF1 on the risk for metabolic syndrome.

Weitere Episoden von „Medizin - Open Access LMU - Teil 16/22“

• An Evolutionary Interpretation of Teleostean Forebrain Anatomy 1. Januar 2009
• Auditory Processing in Children with Specific Language Impairments: Are there Deficits in Frequency Discrimination, Temporal Auditory Processing or General Auditory Processing? 1. Januar 2009
• Beurteilung des Therapieerfolgs – konventionelle versus neue Methoden 1. Januar 2009
• Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study 1. Januar 2009
• Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling 1. Januar 2009
• Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome 1. Januar 2009
• Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival 1. Januar 2009
• Current Oncological Treatment of Patients with Pancreatic Cancer in Germany: Results from a National Survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society 1. Januar 2009
• Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves 1. Januar 2009
• Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor 1. Januar 2009
• Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) 1. Januar 2009
• Diagnostik und Therapie von Lebermetastasen bei kolorektalem Primärtumor 1. Januar 2009
• Die Evidenz der Klima- und Thalassotherapie 1. Januar 2009
• Die Homöopathie im Spannungsfeld zwischen aristotelischer und moderner Wissenschaft 1. Januar 2009
• A Technical Note on Quantum Dots for Multi-Color Fluorescence in situ Hybridization 1. Januar 2009

Alle Episoden von Medizin - Open Access LMU - Teil 16/22 · Mehr Bildung-Podcasts