FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases

Episode von Medizin - Open Access LMU - Teil 16/22 von Ludwig-Maximilians-Universität München · 1. Januar 2009

Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease. The level and composition of LC-PUFAs in the human body is highly dependent on their intake in the diet or on the intake of fatty acid precursors, which are endogenously elongated and desaturated to physiologically active LC-PUFAs. The most important enzymes in this reaction cascade are the Delta(5) and Delta(6) desaturase. Several studies in the last few years have revealed that single nucleotide polymorphisms (SNPs) in the 2 desaturase encoding genes (FADS1 and FADS2) are highly associated with the concentration of omega-6 and omega-3 fatty acids, showing that beside nutrition, genetic factors also play an important role in the regulation of LC-PUFAs. This review focuses on current knowledge of the impact of genetic polymorphisms on LC-PUFA metabolism and on their potential role in the development of atopic diseases. Copyright (c) 2009 S. Karger AG, Basel

Weitere Episoden von „Medizin - Open Access LMU - Teil 16/22“

• An Evolutionary Interpretation of Teleostean Forebrain Anatomy 1. Januar 2009
• Auditory Processing in Children with Specific Language Impairments: Are there Deficits in Frequency Discrimination, Temporal Auditory Processing or General Auditory Processing? 1. Januar 2009
• Beurteilung des Therapieerfolgs – konventionelle versus neue Methoden 1. Januar 2009
• Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study 1. Januar 2009
• Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling 1. Januar 2009
• Cisplatin-Based Chemotherapy for Pulmonary Metastasized Germ Cell Tumors of the Testis - Be Aware of Acute Respiratory Distress Syndrome 1. Januar 2009
• Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival 1. Januar 2009
• Current Oncological Treatment of Patients with Pancreatic Cancer in Germany: Results from a National Survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society 1. Januar 2009
• Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves 1. Januar 2009
• Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor 1. Januar 2009
• Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) 1. Januar 2009
• Diagnostik und Therapie von Lebermetastasen bei kolorektalem Primärtumor 1. Januar 2009
• Die Evidenz der Klima- und Thalassotherapie 1. Januar 2009
• Die Homöopathie im Spannungsfeld zwischen aristotelischer und moderner Wissenschaft 1. Januar 2009
• A Technical Note on Quantum Dots for Multi-Color Fluorescence in situ Hybridization 1. Januar 2009

Alle Episoden von Medizin - Open Access LMU - Teil 16/22 · Mehr Bildung-Podcasts