Glycobiology of the olfactory system

Episode von Medizin - Open Access LMU - Teil 12/22 von Ludwig-Maximilians-Universität München · 1. Januar 1998

The olfactory system is a highly plastic region of the nervous system. Continuous remodeling of neuronal circuits in the olfactory bulb takes place throughout life as a result of constant turnover of primary sensory olfactory neurons in the periphery. Glycoconjugates are very important in olfactory development, regeneration and function. This article deals with different aspects of glycobiology relevant for the olfactory system. Various anatomical? developmental and functional subdivisions of the olfactory system have been labeled with exogenous lectins. The application of reverse lectin histochemistry resulted in the visualization of endogenous lectins, involved in fasciculation of olfactory axons. Numerous glycoproteins, among them members of the immunoglobulin superfamily, the cadherins and integrins as well as different,glycolipids and proteoglycans can act as surface adhesion molecules in the olfactory system. The olfactory-specific form of the sialoglycoprotein neural cell adhesion molecule is implicated in olfactory neuronal and axonal guidance. Glycoconjugates including laminin, fibronectin and proteoglycans are abundant components of the olfactory extracellular matrix, influencing neurite outgrowth and cellular migration. Immunohistochemical labeling has revealed occurrence of the carbohydrate differentiation antigen, playing a role in neurulation and morphogenesis of the very early olfactory system. The synaptic vesicle glycoprotein, appearing also early in olfactory development, is used as a marker of olfactory tumors. Finally, membrane and transmembrane glycoconjugates as well as secreted glycoconjugates may act as olfactory receptor molecules.

Weitere Episoden von „Medizin - Open Access LMU - Teil 12/22“

• Acneiform dermatoses 1. Januar 1998
• Animal lectins as cell adhesion molecules 1. Januar 1998
• Antimicrobial susceptibility testing of dermatophytes - Comparison of the agar macrodilution and broth microdilution tests 1. Januar 1998
• Application of a novel method for subsequent evaluation of sinusoids and postsinusoidal venules after ischemia-reperfusion injury of rat liver 1. Januar 1998
• Aquarium dermatitis: Cercarial dermatitis in an aquarist 1. Januar 1998
• Beobachtungsstudien im Rahmen eines naturheilkundlichen Klinikverbunds :Teil I: Methoden und Übersicht der Ergebnisse in den beteiligten Kliniken 1. Januar 1998
• Beobachtungsstudien im Rahmen eines naturheilkundlichen Klinikverbunds :Teil II: Detaillierte Ergebnisse der Klinik für Traditionelle ChinesischeMedizin Kötzting 1. Januar 1998
• Beobachtungsstudien im Rahmen eines naturheilkundlichen Klinikverbunds :Teil III: Zwischenergebnisse der diagnosespezifischen Dokumentation Migräne in der Klinik für TraditionelleChinesische Medizin Kötzting 1. Januar 1998
• Beobachtungsstudien im Rahmen eines naturheilkundlichen Klinikverbunds :Teil IV: Methodische Aspekte, Diskussion und Empfehlungen 1. Januar 1998
• Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection 1. Januar 1998
• Correlation of qEEG with PET in schizophrenia 1. Januar 1998
• Current study concepts for refractory ovarian carcinoma 1. Januar 1998
• Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins 1. Januar 1998
• Differential treatment of bipolar disorder with old and new antiepileptic drugs 1. Januar 1998
• Acetazolamide in the treatment of acute mania - A case report 1. Januar 1998

Alle Episoden von Medizin - Open Access LMU - Teil 12/22 · Mehr Bildung-Podcasts