Endocrine cells share expression of N-CAM with neurones

Episode von Medizin - Open Access LMU - Teil 06/22 von Ludwig-Maximilians-Universität München · 1. Januar 1987

The reeent explosive interest in eell adhesion

molecules (CAMs) is a direet eonsequence of the

fundamental roles they are thought to play during

early embryogenesis and tissue formation [1,2].

The most weIl known of them, studied independently

under the names of N-CAM [3]

(neural-CAM), 02 protein [4] and BSP-2 [5], has

been shown to consist in brain of a family of three

glyeoproteins of Mr 180000, 140000 and 120000

[6,7] which are implicated in neurone-neurone

adhesion by a homophilie binding meehanism

[8,9]. While N-CAM was originally considered to

be limited to neurones in adult tissues, ultrastruetural

immunoeytochemical studies have sinee provided

unequivocal evidenee that glial cells, both

astrocytes [6,10] and Schwann cells [11], also express

N-CAM (see also [12,13]). Apart from a very

limited expression by skeletal muscle at the neuromuscular

junetion [14], its expression in the adult

Correspondence address: O.K. Langley, Unite 44 de

I'INSERM, and Centre de Neurochirnie du CNRS, 5 rue

Blaise Pascal, 67084 Strasbourg Cedex, France

has been largely though not exclusively considered

to be limited to nervous tissues. N-CAM has been

found in eertain eells outside the nervous system

(e.g. chromaffin eells in the adrenal medulla [11])

but such eells are derived from the neural crest.

Here we extend our previous observations on endocrine

eells in the adrenal gland and investigate

the possible expression of N-CAM by other endoerine

eells whieh have a non-neural origin. The present

results indieate a mueh wider distribution of

N-CAM in adult tissues than has previously been

supposed. N-CAM is shown by immunoeytoehemistry

to be expressed by several endoerine eells

of non-neural origin. Immunoehemieal data eonfirm

the presenee of N-CAM determinants typical

of brain in endoerine eells although the relative

proportions differ markedly. In addition, in two of

the tissues examined a lower molecular mass NCAM

positive polypeptide was also detected.

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