Medizin - Open Access LMU - Teil 21/22

von Ludwig-Maximilians-Universität München · Bildung

Die Universitätsbibliothek (UB) verfügt über ein umfangreiches Archiv an elektronischen Medien, das von Volltextsammlungen über Zeitungsarchive, Wörterbücher und Enzyklopädien bis hin zu ausführlichen Bibliographien und mehr als 1000 Datenbanken reicht. Auf iTunes U stellt die UB unter anderem eine Auswahl an elektronischen Publikationen der Wissenschaftlerinnen und Wissenschaftler an der LMU bereit. (Dies ist der 21. von 22 Teilen der Sammlung 'Medizin - Open Access LMU'.)

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Episoden

A comparative analysis of the properties of regulated promoter systems commonly used for recombinant gene expression in Escherichia coli
1. Januar 2013
Background: Production of recombinant proteins in bacteria for academic and commercial purposes is a well established field; however the outcomes of process developments for…
A genotype-specific, randomized controlled behavioral intervention to improve the neuroemotional outcome of cardiac surgery: study protocol for a randomized controlled trial
1. Januar 2013
Background: Cardiac surgery is one of the most commonly performed surgical procedures worldwide with > 700,000 surgeries in 2006 in the US alone. Cardiac surgery results in a…
A new web-based method for automated analysis of muscle histology
1. Januar 2013
Background: Duchenne Muscular Dystrophy is an inherited degenerative neuromuscular disease characterised by rapidly progressive muscle weakness. Currently, curative treatment is…
Acceptance of routine or case-based inquiry for intimate partner violence: a mixed method study
1. Januar 2013
Background: The prevalence and detrimental health effects of intimate partner violence have resulted in international discussions and recommendations that health care…
Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial
1. Januar 2013
Background: Flupirtine is an analgesic with muscle-relaxing properties that activates Kv7 potassium channels. Kv7 channels are expressed along myelinated and unmyelinated…
Aequilibrium prudentis: on the necessity for ethics and policy studies in the scientific and technological education of medical professionals
1. Januar 2013
Background: The importance of strong science, technology, engineering, and mathematics education continues to grow as society, medicine, and the economy become increasingly…
An AUC-based permutation variable importance measure for random forests
1. Januar 2013
Background: The random forest (RF) method is a commonly used tool for classification with high dimensional data as well as for ranking candidate predictors based on the so-called…
Autosomal recessive spastic ataxia of Charlevoix Saguenay (ARSACS): expanding the genetic, clinical and imaging spectrum
1. Januar 2013
Background: Mutations in SACS, leading to autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), have been identified as a frequent cause of recessive early-onset…
`Burden to others' as a public concern in advanced cancer: a comparative survey in seven European countries
1. Januar 2013
Background: Europe faces an enormous public health challenge with aging populations and rising cancer incidence. Little is known about what concerns the public across European…
Characterization of in vivo chemoresistant human hepatocellular carcinoma cells with transendothelial differentiation capacities
1. Januar 2013
Background: Chemotherapeutic treatment of hepatocellular carcinoma often leads to chemoresistance during therapy or upon relapse of tumors. For the development of better…
Conscious Presence and Self Control as a measure of situational awareness in soldiers - A validation study
1. Januar 2013
Background: The concept of `mindfulness' was operationalized primarily for patients with chronic stressors, while it is rarely used in reference to soldiers. We intended to…
Contrast enhanced transesophageal echocardiography in patients with atrial fibrillation referred to electrical cardioversion improves atrial thrombus detection and may reduce associated thromboembolic events
1. Januar 2013
Aims: Transesophageal echocardiography (TEE) is the gold standard for the detection of thrombi in patients with atrial fibrillation (AF) before undergoing early electrical…
Current experience with applying the GRADE approach to public health interventions: an empirical study
1. Januar 2013
Background: The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach has been adopted by many national and international organisations as a…
Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH
1. Januar 2013
Background: Data describing real-life management and treatment of community-acquired pneumonia (CAP) in Europe are limited. REACH (NCT01293435) was a retrospective, observational…
Diversity of the var gene family of Indonesian Plasmodium falciparum isolates
1. Januar 2013
Background: The large polymorphic protein PfEMP1 is encoded by the var gene family. PfEMP1 has been shown to play an important role as cytoadherence ligand on the surface of…
Driving forces for changes in geographical distribution of Ixodes ricinus ticks in Europe
1. Januar 2013
Many factors are involved in determining the latitudinal and altitudinal spread of the important tick vector Ixodes ricinus (Acari: Ixodidae) in Europe, as well as in changes in…
Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
1. Januar 2013
Background: Metabolomics helps to identify links between environmental exposures and intermediate biomarkers of disturbed pathways. We previously reported variations in…
Escherichia coli- and Staphylococcus aureus-induced mastitis differentially modulate transcriptional responses in neighbouring uninfected bovine mammary gland quarters
1. Januar 2013
Background: The most important disease of dairy cattle is mastitis, caused by the infection of the mammary gland by various micro-organisms. Although the transcriptional response…
Genotyping 1000 yeast strains by next-generation sequencing
1. Januar 2013
Background: The throughput of next-generation sequencing machines has increased dramatically over the last few years; yet the cost and time for library preparation have not…
Her-2/neu expression is a negative prognosticator in ovarian cancer cases that do not express the follicle stimulating hormone receptor (FSHR)
1. Januar 2013
Background: Anti-Her-2 treatment is successfully administered to Her-2 overexpressing breast cancer patients and significantly implicates upon their survival. Building on these…
High throughput transcriptome analysis of lipid metabolism in Syrian hamster liver in absence of an annotated genome
1. Januar 2013
Background: Whole transcriptome analyses are an essential tool for understanding disease mechanisms. Approaches based on next-generation sequencing provide fast and affordable…
Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma
1. Januar 2013
Nuclear magnetic resonance spectroscopy (NMR) provides robust readouts of many metabolic parameters in one experiment. However, identification of clinically relevant markers in…
Impact of joint contractures on functioning and social participation in older individuals - development of a standard set (JointConFunctionSet): study protocol
1. Januar 2013
Background: Joint contractures are frequent in older individuals in geriatric care settings. Even though they are used as indicator of quality of care, there is neither a common…
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
1. Januar 2013
Background: The p53 protein is the best studied target in human cancer. For decades, p53 has been believed to act mainly as a tumor suppressor and by transcriptional regulation.…
In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice
1. Januar 2013
Background: Leukocytes are believed to be involved in delayed cell death following traumatic brain injury (TBI). However, data demonstrating that blood-borne inflammatory cells…
Interleukin-1 beta receptor expressed by modified vaccinia virus Ankara interferes with interleukin-1 beta activity produced in various virus-infected antigen-presenting cells
1. Januar 2013
Background: Modified vaccinia virus Ankara (MVA) is a highly attenuated virus and a promising vaccine vector with potent immune stimulating properties. Deletion of the gene…
Kidney disease in lupus is not always `lupus nephritis'
1. Januar 2013
In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current…
Learning the facts in medical school is not enough: which factors predict successful application of procedural knowledge in a laboratory setting?
1. Januar 2013
Background: Medical knowledge encompasses both conceptual (facts or ``what{''} information) and procedural knowledge ({''}how{''} and ``why{''} information). Conceptual knowledge…
Mature results of a randomized trial comparing two fractionation schedules of high dose rate endoluminal brachytherapy for the treatment of endobronchial tumors
1. Januar 2013
Purpose: To determine the efficacy of high dose rate endobronchial brachytherapy (HDR-BT) for the treatment of centrally located lung tumors, two different fractionation…
miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors
1. Januar 2013
Background: Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscle disorder, which is linked to the contraction of the D4Z4 array at chromosome 4q35.…
NOD-scid IL2R gamma(null) mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways
1. Januar 2013
Background: Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific activation…
Overall mental distress and health-related quality of life after solid-organ transplantation: results from a retrospective follow-up study
1. Januar 2013
Background: Our retrospective follow-up study aimed to explore the degree of overall mental distress in a cohort of solid-organ transplantation (SOT) recipients after liver,…
Physical activity and beverage consumption in preschoolers: focus groups with parents and teachers
1. Januar 2013
Background: Qualitative research is a method in which new ideas and strategies can be discovered. This qualitative study aimed to investigate parents' and teachers' opinions on…
Physical activity and its correlates in children: a cross-sectional study (the GINIplus & LISAplus studies)
1. Januar 2013
Background: Physical inactivity among children is an increasing problem that adversely affects children's health. A better understanding of factors which affect physical activity…
Propionic acidemia: clinical course and outcome in 55 pediatric and adolescent patients
1. Januar 2013
Background: Propionic acidemia is an inherited disorder caused by deficiency of propionyl-CoA carboxylase. Although it is one of the most frequent organic acidurias, information…
Prospective European-wide multicentre study on a blood based real-time PCR for the diagnosis of acute schistosomiasis
1. Januar 2013
Background: Acute schistosomiasis constitutes a rare but serious condition in individuals experiencing their first prepatent Schistosoma infection. To circumvent costly and…
Proteomic profiling in schizophrenia: enabling stratification for more effective treatment
1. Januar 2013
Schizophrenia is a heterogeneous psychiatric disorder characterized by an array of clinical manifestations. Although the best known manifestations include serious effects on mood…
Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement
1. Januar 2013
Introduction: Hydroxyethyl starch (HES) is a commonly used colloid in critically ill patients. However, its safety has been questioned in recent studies and meta-analyses.…
Recommendations on treatment for IPF
1. Januar 2013
Patient management in Idiopathic Pulmonary Fibrosis (IPF) is largely based on societal guidelines and recommendations. A recent update by the American Thoracic Society (ATS),…
Serum KL-6 is a predictor of outcome in pulmonary alveolar proteinosis
1. Januar 2013
Background: Pulmonary alveolar proteinosis (PAP) is a rare disorder characterised by abundant alveolar accumulation of surfactant lipoproteins. Serum levels of KL-6, high…

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Die neueste Episode „A comparative analysis of the properties of regulated promoter systems commonly used for recombinant gene expression in Escherichia coli“ erschien am 1. Januar 2013.

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